The extraordinary story of how the human brain evolved… and is still evolving.

We’ve come a long way. The earliest human had a brain as small as a child’s fist; ours are four times bigger, with spectacular abilities and potential we are only just beginning to understand.

This is How the Mind Changed, a seven-million-year journey through our own heads, packed with vivid stories, groundbreaking science, and thrilling surprises. Discover how memory has almost nothing to do with the past; meditation rewires our synapses; magic mushroom use might be responsible for our intelligence; climate accounts for linguistic diversity; and how autism teaches us hugely positive lessons about our past and future.

Dr. Joseph Jebelli’s In Pursuit of Memory was shortlisted for the Royal Society Science Book Prize and longlisted for the Wellcome. In this, his eagerly awaited second book, he draws on deep insights from neuroscience, evolutionary biology, psychology, and philosophy to guide us through the unexpected changes that shaped our brains. From genetic accidents and environmental forces to historical and cultural advances, he explores how our brain’s evolution turned us into Homo sapiens and beyond.

A single mutation is all it takes.

For readers of Atul Gawande, Siddhartha Mukherjee, and Henry Marsh, a riveting, gorgeously written biography of one of history’s most fascinating and confounding diseases — Alzheimer’s — from its discovery more than 100 years ago to today’s race towards a cure.

Alzheimer’s is the great global epidemic of our time, affecting millions worldwide — there are more than 5 million people diagnosed in the US alone. And as our population ages, scientists are working against the clock to find a cure.

Neuroscientist Joseph Jebelli is among them. His beloved grandfather had Alzheimer’s and now he’s written the book he needed then — a very human history of this frightening disease. But In Pursuit of Memory is also a thrilling scientific detective story that takes you behind the headlines. Jebelli’s quest takes us from nineteenth-century Germany and post-war England, to the jungles of Papua New Guinea and the technological proving grounds of Japan; through America, India, China, Iceland, Sweden, and Colombia. Its heroes are scientists from around the world — many of whom he’s worked with — and the brave patients and families who have changed the way that researchers think about the disease.

This compelling insider’s account shows vividly why Jebelli feels so hopeful about a cure, but also why our best defense in the meantime is to understand the disease. In Pursuit of Memory is a clever, moving, eye-opening guide to the threat one in three of us faces now.