It’s 1976. Despite fierce international controversy over whether in vitro fertilization (IVF) should ever be performed in humans, doctors around the world race to be first to produce a baby through this procedure.

Dr. Colin Sanford, a brilliant, ambitious obstetrician in the Pacific Northwest city of Emerald, has a plan. He recruits Dr. Giselle Hearn, an experienced laboratory geneticist-embryologist at the university who’s frustrated by the ultraconservative policies of her department chairman. Drs. Sanford and Hearn, working secretly, set out to put their names in history books. Unfortunately, a secret that big is hard to keep, and Alma Wanego, Dr. Hearn’s lab supervisor, catches on and demands a blackmail payment. Several months later, Dr. Sanford’s patient, Joyce Kennett, gives birth to a healthy boy, and Sanford prepares to make an announcement at a press conference. But before that happens, Joyce Kennett’s marginally-schizophrenic husband kills Dr. Hearn and then himself.

Police detective Bernie Baumgartner’s investigation is hampered by pressure from influential people at the university who want to control sensationalism that might harm the institution. The chief of police chalks it up to the work of a mentally unstable man who may have forgotten to take his medication and considers the case closed. But dogged, tenacious Baumgartner suspects that Sanford and Hearn were in fact doing IVF, that they succeeded with the Kennetts, and that murder, suicide, and other crimes were the fallout.

A double cat-and-mouse game develops between doctor and detective, and as stakes escalate, truth becomes an increasingly evasive commodity.

It’s 1916, and time’s running out for Scott Joplin. Before he dies, he wants to provide for his wife and secure his place in musical history.

Joplin has written a musical drama, and his young piano student, Martin Niederhoffer, convinces him to try to get Irving Berlin to publish and produce the work. The next day, Niederhoffer walks into his office and finds Joplin crouched over the blood-soaked body of a young man. He hustles his teacher away, but the two are seen leaving the building.

When Berlin flatly denies ever having received Joplin’s play, young Niederhoffer engages the services of hit man Footsie Vinny, who gives Berlin a five-day deadline to come up with the manuscript.

Then, just when things couldn’t get worse, Niederhoffer’s girlfriend is kidnapped. Can the ailing musician be exonerated before it is too late?

It’s 1951 in Sedalia, Missouri, and ragtime is making a comeback. When Brun Campbell, the old Ragtime Kid, learns of a journal kept by Scott Joplin, he hopes he can use it to convince Sedalia’s movers and shakers to set up a ragtime museum. But plenty of other people also want that journal, including a historian who wants to publish it, an old friend of Joplin’s who wants to suppress it, and two Klansmen who don’t care if they have to kill someone to get it. What’s one murder, compared to the Klansmen’s grand plan to blow up the high-school auditorium with its integrated audience during a ceremony honoring Joplin? In the middle of this imbroglio is Alan Chandler, a young pianist in love with ragtime. If Alan can stay alive, he may be able to prevent catastrophe and learn what it really means to be black in mid-twentieth-century America.